Source Data
Source Data Peer review information Nature Communications thanks Thomas Gallagher and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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These authors contributed equally: Xiuyuan Ou, Yan Liu, Xiaobo Lei.

Supplementary information
Supplementary information is available for this paper at 10.1038/s41467-020-15562-9.

Acknowledgements
This work was supported by grants from Chinese Science and Technology Key Projects (2020YFC0841000), National Natural Science Foundation of China (31670164 and 31970171 to Z.Q., and 81930063 to J.W.), Chinese Science and Technology Key Projects (2017ZX0103004), COVID-19 Emergency Fund from CAMS (2020HY320001), and the CAMS Innovation Fund for Medical Sciences (2016-12M-1-014 to J.W.)

Author contributions
Z.Q. and J.W. conceived the projects, Z.Q., J.W., and Q.J. coordinated the projects. Z.Q., J.W., and Q.J. designed the experiments with the help of X.O., Y.L., X.L., L.R., L.G., and Z.X. X.O., Y.L., X.L., P.L., D.M., R.G., T.C., J.H. Z.M., and X.C., performed all the experiments. Z.Q., J.W., and Q.J. analyzed the data with help of X.O., Y.L., X.L., L.R., L.G., Z.X., J.C., and K.H. Z.Q., and J.W. wrote the manuscript with help of other authors.

Data availability
The data supporting the findings of this study are available from the authors upon request. The source data underlying Figs. 1b–j, 2a, b, d, 3a–f, 4a, c–e, 5b, e and 6a, b and Table 1 and Supplementary Figs. 1 and 3 are provided as a Source Data file.

Competing interests
The authors declare no competing interests.