In conclusion, our study showed that chest CT examination was very effective in detecting pulmonary parenchymal abnormalities in the natural course of COVID-19. Multiple GGOs with consolidations in the peripheral lung was the primary CT characteristic of COVID-19. The halo sign may be a special CT feature in the early stage of COVID-19, while a significantly increased CT score may indicate the aggravation of COVID-19 in the progressive stage. In patients with dyspnea and respiratory distress, CT examination is very effective in the preclinical screening of patients with COVID-19.