Because COVID-19 is believed to have an interpersonal human-to-human transmission [2], either home residence or a travel history to Wuhan—coupled with exposure to known or suspected cases—is paramount to raise clinical suspicion. The clinical, laboratory, and imaging characteristics of the four patients described in the current report are consistent with a diagnosis of COVID-19. Herein, we therefore describe for the first time the 18F-FDG PET/CT findings of four patients with COVID-19.