In 2010, Shi et al. isolated a SARS-like coronavirus which was highly homologous to the SARS-CoV, confirming that Rhinolophus sinicus (Chinese rufous horseshoe bat) was a natural host of the SARS-CoV [46]. Bats are known to be hosts for 30 coronaviruses based on complete genomic sequences analysis [47]. Epidemiological investigations have shown that civet cats in the wildlife market were the direct source of SARS-CoV [48]. Among the four patients with SARS discovered during the winter of 2003-2004, two were waitresses at a restaurant in Guangzhou, China, and one was a customer who ate in the restaurant a short distance from a civet cage. All six civets in this cage were tested positive for SARS-CoV [48].