Our data suggested that GA targets virus-cell fusion. To assess the activity of GA C15:1 on virus-cell fusion we modeled virus-cell fusion by the fusion of cells expressing viral fusion proteins to target cells. Cell-cell fusion was monitored by the spread of fluorescent dyes. Based on crystallographically identified three-dimensional structures, the folds of all virus fusion proteins fall into one of three classes. Effector COS7 cells were transfected to express all three classes of fusion proteins (Table S2), including ZIKV, HIV, EBOV, IAV, SFV, VEEV, VSV and EBV.