COVID-19 appeared just one month before the Spring Festival of China, and the massive population flow has brought great challenges for disease prevention and control. This virus can be transmitted from human to human and no effective treatment drug has been found. The most effective prevention and control measures are to find suspected patients and close contacts, confirm patients and virus carriers, and block the transmission through isolation, disinfection, and personal protection. Therefore, early detection, isolation, and treatment of patients are the key measures to control the source of infection and reduce the infection rate. It is also crucial to avoid nosocomial infection by strengthening the management of medical staff and patients. Health education on knowledge for disease prevention and control is also important. Finally, if we want to eliminate the threat of this novel coronavirus pneumonia similar to SARS, we need to learn more about the pathogenesis of the virus and develop specific vaccines and therapeutic drugs as soon as possible.