Table 1  Details of studies representing protein database structures of major targets in coronavirus and their structures
PDB ID  Details  Inhibitor  IC50  Reference
N protein
4KXJ  Interaction between PJ34 and NTD of N protein of HCoV-OC43  PJ34  -  [26]
3V3P  Structure not released    [30]
4LM7  Interactions of NTD of N protein of HCoV-OC43 with UMP  -   [26]
4LI4  Interactions of NTD of N protein of HCoV-OC43 with AMP  -   [26]
Protease
4TWY  3CLPro of SARS-CoV with an inhibitor  3BL   [27]
4TWW  3CLPro of SARS-CoV with an inhibitor  41  63 µM  [27]
4WY3  3CLPro of SARS-CoV with an inhibitor  3X5  240 µM  [27]
4OVZ  CoV PLPro complexed with inhibitor  P85  490 nM  [31]
3MJ5  SARS-CoV PLPro complexed with inhibitor  GRM  320 nM  [32]
2FE8  SARS-CoV PLPro  -  -  [33]
1UK4  SARS-CoV 3CLPro and its interactions with an inhibitor  Substrate analog hexapeptidyl CMK inhibitor  IC50 ca. 2 mM  [34]
1UJ1, 1UK3, 1UK2  SARS-CoV M-pro, apo-enzyme at different pH  -  -  [34]
3VB6  SARS-CoV 3CLPro in complex with C6Z  C6Z  39 µM  [35]
3VB5  SARS-CoV 3CLPro with C4Z  C4Z  1.3-4.6 µM  [35]
3TLO  HCoV-NL63 3CLPro  -  -  [3637]
6LU7  Main protease of 2019-nCoV and its complex with N3 (inhibitor)  -  -  [38]
Spike protein
5ZUV  HR1 motif of HCoV-229E in complex with EK1  Modified OC43-HR2P peptide (EK1)  0.19-0.62 µM  [39]
5ZVM  EK1 in complex with SARS HR1 motif    [39]
5X4S  NTD of SARS-CoV S protein    [40]
5WRG  SARS-CoV S protein    [41]
6Q05  MERS-CoV S structure in complex with Sialyl-Lewis    [42]
6ACG  SARS-CoV S protein: ACE-2 (conformation 1) complex    [43]
6ACK  SARS-CoV S protein: ACE-2 (conformation 3) complex    [43]
3SCI  RBD of S protein interaction with ACE-2    [44] to be published
NTD=N-terminal domain, CoV=Coronovirus, 3CLPro=3C-like protease, PLpro=Papain-like protease, MERS=Middle East respiratory syndrome, SARS=Severe acute respiratory syndrome, ACE-2=Angiotensin converting enzyme-2, RBD=Receptor-binding domain, nCoV=Novel coronavirus, S protein=Spike protein