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These authors contributed equally: Yadi Zhou, Yuan Hou

Supplementary information
Supplementary Information accompanies the paper at (10.1038/s41421-020-0153-3).

Acknowledgements
This work was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) under Award Number K99 HL138272 and R00 HL138272 to F.C. The content of this publication does not necessarily reflect the views of the Cleveland Clinic.

Author contributions
F.C. conceived the study. Y.Z. and Y.H. developed the network methodology and performed all computational experiments. J.S., Y.Z., Y.H., and W.M. performed data analysis. F.C., Y.Z., and Y.H. wrote and critically revised the manuscript with contributions from other co-authors.

Data availability
All predicted repurposable drugs and network-predicted drug combinations can be freely accessed at https://github.com/ChengF-Lab/2019-nCoV.

Code availability
All codes can be freely accessed at https://github.com/ChengF-Lab/2019-nCoV.

Conflict of interest
The authors declare that they have no conflict of interest.