angle d_{CT} \right\rangle = \frac{1}{\vert\vert C \vert\vert +\vert\vert T \vert\vert}\left({\sum\limits_{c \in C}} {\min}_{t \in T}\,d\left( {c,t} \right) + {\sum\limits_{t \in T}} {\min}_{c \in C}\,d\left(c,t\right) \right),$$\end{document}dCT=1∣∣C∣∣+∣∣T∣∣∑c∈Cmint∈Tdc,t+∑t∈Tminc∈Cdc,t,where d(c, t) is the shortest distance between gene c and t in the human protein interactome. The network proximity was converted to Z-score based on permutation tests:2 \documentclass[12pt]{minimal} 				\usepackage{amsmath} 				\usepackage{wasysym} 				\usepackage{amsfonts} 				\usepackage{amssymb} 				\usepackage{amsbsy} 				\usepackage{mathrsfs} 				\usepackage{upgreek} 				\setlength{\oddsidemargin}{-69pt} 				\begin{document}$$Z_{d_{CT}} = \frac{{d_{CT} - \overline {d_r} }}{{\sigma _r}},$$\end{document}ZdCT=dCT−dr¯σr,where \documentclass[12pt]{minimal} 				\usepackage{amsmath} 				\usepackage{wasysym} 				\usepa