This study was supported by grants awarded to YY by the National Natural Science Foundation of China (81870019), Guangdong Provincial Natural Science Foundation (2018A030313554), National Key R&D Program of China (2018YFC0910601); DYW by the National Medical Research Council, Singapore (NMRC/CIRG/1458/2016); KST is a recipient of fellowship support from European Allergy and Clinical Immunology (EAACI) Research Fellowship 2019.