PMC:7054527 / 3498-4973
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7054527","sourcedb":"PMC","sourceid":"7054527","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7054527","text":"Usually, several members of the coronavirus cause mild respiratory disease in humans; however, SARS-CoV and the Middle East respiratory syndrome coronavirus (MERS-CoV) explored in 2002–2003 and in 2012, respectively, caused fatal severe respiratory diseases20–22. The SARS-CoV and MERS-CoV belong to the β-CoV23,24. 2019-nCoV explored in Wuhan also belongs to the β-CoV according to the phylogenetic analysis based on the viral genome10,11. Although the nucleotide sequence similarity is less than 80% between 2019-nCoV and SARS-CoV (about 79%) or MERS-CoV (about 50%), 2019-nCoV can also cause the fetal infection and spread more faster than the two other coronaviruses7,9,11,25–27. The genome nucleotide sequence identity between a coronavirus (BatCoV RaTG13) detected in the bat Rhinolophus affinis from Yunnan Province, China, and 2019-nCoV, was 96.2%, indicating that the natural host of 2019-nCoV may also be the Rhinolophus affinis bat11. However, the differences may also suggest that there is an or more intermediate hosts between the bat and human. A research team from the South China Agricultural University has invested more than 1 000 metagenomic samples from pangolins, and found that 70% pangolins contained β-CoV28. One of the coronaviruses they isolated from the pangolins comprised a genome that was very similar with that from 2019-nCoV, and the genome sequence similarity was 99%, indicating that the pangolin may be the intermediate host of 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