Wuhan is a transportation hub of China, it is a highly dense city and has a large population of more than 14 million in 2019. The World Health Organization (WHO) had a meeting on January 30, 2020 and they declared the coronavirus outbreak from China a public health emergency of international concern. Further, there are lots of concerns and debates all over the world, indicating a need for more understanding of China’s systems in responding to the outbreak. Therefore, based on our firsthand experience of working with few of the COVID-19 cases, the purpose of this article is to have a brief report of current development, challenges, and future directions of the coronavirus outbreak in Wuhan.