In this study, we developed RP transmission model, which considering the routes from reservoir to person and from person to person of SARS-CoV-2 respectively. We used the models to fit the reported data in Wuhan City, China from published literature [3]. The simulation results showed that the R0 of SARS-CoV-2 was 3.58 from person to person. There was a research showed that the R0 of SARS-CoV-2 was 2.68 (95% CI: 2.47–2.86) [8]. Another research showed that the R0 of SARS-CoV-2 was 2.2 (95% CI: 1.4–3.9) [3]. The different values might be due to the different methods. The methods which Li et al. employed were based on the epidemic growth rate of the epidemic curve and the serial interval [3]. Our previous study showed that several methods could be used to calculate the R0 based on the epidemic growth rate of the epidemic curve and the serial interval, and different methods might result in different values of R0 [26]. Our results also showed that the R0 of SARS-CoV-2 was 2.30 from reservoir to person which was lower than that of person to person. This means that the transmission route was mainly from person to person rather than from reservoir to person in the early stage of the transmission in Wuhan City. However, this result was based on the limited data from a published literature, and it might not show the real situation at the early stage of the transmission.