SUPPLEMENTARY MATERIALS Supplementary Data 1 Laboratory procedures and detailed clinical course of Patient 2 Supplementary Table 1 Clinical course and viral loads of Patient 1 according to the timeline from symptom onset Supplementary Table 2 Clinical course and viral loads of Patient 2 according to the timeline from symptom onset Supplementary Table 3 Estimated number of viral copy of respiratory specimens Supplementary Fig. 1 Viral load kinetics according to the clinical course of Patient 1, presented by reverse Ct value. (A) Viral load kinetics of respiratory specimen, (B) Viral load kinetics of blood specimen, (C) Viral load kinetics of urine and stool specimen. Supplementary Fig. 2 Viral load kinetics according to the clinical course of Patient 2, presented by reverse Ct value. (A) Viral load kinetics of respiratory specimen, (B) Viral load kinetics of blood specimen, (C) Viral load kinetics of urine and stool specimen. Supplementary Fig. 3 Images of Patient 2. (A) Chest X-ray taken on admission, January 24, 2010 (day 15 from symptom onset). (B) High resolution computed tomography taken on January 25, 2010 (day 16 from symptom onset).