Funding. This work was supported by grants from the National Natural Science Foundation of China (Nos. 81770032, 81570034, 81300027), Foundation for Distinguished Young Scholars of the First Affiliated Hospital of Anhui Medical University, Program for the Youth Distinguished Talents of Anhui Medical University, Doctoral research foundation of the First Affiliated Hospital of Anhui Medical University (No.3101005002442), and Anhui Key Lab of Geriatric molecular medicine.