Methamphetamine (Meth) is an illicit drug abused worldwide, posing major public health challenges (1, 2). Meth use increases the spread and replication of Human Immunodeficiency Virus (HIV-1) by fostering risky sexual behaviors, and by facilitating viral infection and rapid progression to AIDS (3–7). Furthermore, Meth abuse is associated with poor adherence to anti-retroviral therapies (8, 9). A clearer understanding of the mechanisms that mediate the molecular effects of Meth on immune defenses should enhance the design of therapies targeted to patients who abuse the drug.