PMC:7019868 / 4373-5618 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"87","span":{"begin":88,"end":92},"obj":"Species"},{"id":"88","span":{"begin":485,"end":490},"obj":"Species"},{"id":"89","span":{"begin":528,"end":532},"obj":"Species"},{"id":"90","span":{"begin":800,"end":804},"obj":"Species"},{"id":"91","span":{"begin":1025,"end":1029},"obj":"Species"},{"id":"92","span":{"begin":502,"end":516},"obj":"Disease"},{"id":"93","span":{"begin":1192,"end":1199},"obj":"CellLine"}],"attributes":[{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"Tax:28295"},{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"Tax:9606"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"Tax:28295"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"Tax:28295"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"Tax:28295"},{"id":"A92","pred":"tao:has_database_id","subj":"92","obj":"MESH:D001102"},{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"CVCL:K772"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"LAVs have been shown to be the most effective way to elicit protective immunity against PEDV infection [12]. Therefore, to combat the emergence of PED as well as to immediately suppress any future outbreaks, studies have been carried out to develop safe and effective vaccines [13,14]. Aside from serial cell culture or animal passages, the reverse genetic system, which rescues genetically modified attenuated viruses, is now the common approach in generating LAV candidates for both human and animal viral diseases, including PEDV [15,16]. To this end, understanding the molecular biology and identification of virulent/attenuating determinant(s) are necessary for the rational design of potential LAV candidates. Comparison of the genomic differences between the Vero cell-cultured attenuated G2b PEDV and their corresponding parental virulent strains has revealed a common pattern of mutation that particularly affects the S gene [12]. While the observation is reasonable considering the fundamental role of S protein in PEDV infection and induction of host immunity, a recent publication found that a singular S gene exchange had no influence on the virulence of the highly virulent G2b BJ2011C strain and avirulent G1a CHM2013 strain [17]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T23","span":{"begin":304,"end":308},"obj":"Body_part"},{"id":"T24","span":{"begin":771,"end":775},"obj":"Body_part"},{"id":"T25","span":{"begin":929,"end":933},"obj":"Body_part"},{"id":"T26","span":{"begin":1014,"end":1021},"obj":"Body_part"},{"id":"T27","span":{"begin":1117,"end":1121},"obj":"Body_part"}],"attributes":[{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma74402"}],"text":"LAVs have been shown to be the most effective way to elicit protective immunity against PEDV infection [12]. Therefore, to combat the emergence of PED as well as to immediately suppress any future outbreaks, studies have been carried out to develop safe and effective vaccines [13,14]. Aside from serial cell culture or animal passages, the reverse genetic system, which rescues genetically modified attenuated viruses, is now the common approach in generating LAV candidates for both human and animal viral diseases, including PEDV [15,16]. To this end, understanding the molecular biology and identification of virulent/attenuating determinant(s) are necessary for the rational design of potential LAV candidates. Comparison of the genomic differences between the Vero cell-cultured attenuated G2b PEDV and their corresponding parental virulent strains has revealed a common pattern of mutation that particularly affects the S gene [12]. While the observation is reasonable considering the fundamental role of S protein in PEDV infection and induction of host immunity, a recent publication found that a singular S gene exchange had no influence on the virulence of the highly virulent G2b BJ2011C strain and avirulent G1a CHM2013 strain [17]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T11","span":{"begin":93,"end":102},"obj":"Disease"},{"id":"T12","span":{"begin":502,"end":516},"obj":"Disease"},{"id":"T13","span":{"begin":1030,"end":1039},"obj":"Disease"}],"attributes":[{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"LAVs have been shown to be the most effective way to elicit protective immunity against PEDV infection [12]. Therefore, to combat the emergence of PED as well as to immediately suppress any future outbreaks, studies have been carried out to develop safe and effective vaccines [13,14]. Aside from serial cell culture or animal passages, the reverse genetic system, which rescues genetically modified attenuated viruses, is now the common approach in generating LAV candidates for both human and animal viral diseases, including PEDV [15,16]. To this end, understanding the molecular biology and identification of virulent/attenuating determinant(s) are necessary for the rational design of potential LAV candidates. Comparison of the genomic differences between the Vero cell-cultured attenuated G2b PEDV and their corresponding parental virulent strains has revealed a common pattern of mutation that particularly affects the S gene [12]. While the observation is reasonable considering the fundamental role of S protein in PEDV infection and induction of host immunity, a recent publication found that a singular S gene exchange had no influence on the virulence of the highly virulent G2b BJ2011C strain and avirulent G1a CHM2013 strain [17]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T45","span":{"begin":304,"end":308},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T46","span":{"begin":320,"end":326},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T47","span":{"begin":411,"end":418},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T48","span":{"begin":485,"end":490},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T49","span":{"begin":495,"end":501},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T50","span":{"begin":766,"end":775},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T51","span":{"begin":855,"end":858},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T52","span":{"begin":868,"end":869},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T53","span":{"begin":929,"end":933},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T54","span":{"begin":1072,"end":1073},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T55","span":{"begin":1104,"end":1105},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T56","span":{"begin":1117,"end":1121},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"}],"text":"LAVs have been shown to be the most effective way to elicit protective immunity against PEDV infection [12]. Therefore, to combat the emergence of PED as well as to immediately suppress any future outbreaks, studies have been carried out to develop safe and effective vaccines [13,14]. Aside from serial cell culture or animal passages, the reverse genetic system, which rescues genetically modified attenuated viruses, is now the common approach in generating LAV candidates for both human and animal viral diseases, including PEDV [15,16]. To this end, understanding the molecular biology and identification of virulent/attenuating determinant(s) are necessary for the rational design of potential LAV candidates. Comparison of the genomic differences between the Vero cell-cultured attenuated G2b PEDV and their corresponding parental virulent strains has revealed a common pattern of mutation that particularly affects the S gene [12]. While the observation is reasonable considering the fundamental role of S protein in PEDV infection and induction of host immunity, a recent publication found that a singular S gene exchange had no influence on the virulence of the highly virulent G2b BJ2011C strain and avirulent G1a CHM2013 strain [17]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T11","span":{"begin":1014,"end":1021},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"LAVs have been shown to be the most effective way to elicit protective immunity against PEDV infection [12]. Therefore, to combat the emergence of PED as well as to immediately suppress any future outbreaks, studies have been carried out to develop safe and effective vaccines [13,14]. Aside from serial cell culture or animal passages, the reverse genetic system, which rescues genetically modified attenuated viruses, is now the common approach in generating LAV candidates for both human and animal viral diseases, including PEDV [15,16]. To this end, understanding the molecular biology and identification of virulent/attenuating determinant(s) are necessary for the rational design of potential LAV candidates. Comparison of the genomic differences between the Vero cell-cultured attenuated G2b PEDV and their corresponding parental virulent strains has revealed a common pattern of mutation that particularly affects the S gene [12]. While the observation is reasonable considering the fundamental role of S protein in PEDV infection and induction of host immunity, a recent publication found that a singular S gene exchange had no influence on the virulence of the highly virulent G2b BJ2011C strain and avirulent G1a CHM2013 strain [17]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T18","span":{"begin":1122,"end":1130},"obj":"http://purl.obolibrary.org/obo/GO_0015297"},{"id":"T19","span":{"begin":1155,"end":1164},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T20","span":{"begin":1155,"end":1164},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"LAVs have been shown to be the most effective way to elicit protective immunity against PEDV infection [12]. Therefore, to combat the emergence of PED as well as to immediately suppress any future outbreaks, studies have been carried out to develop safe and effective vaccines [13,14]. Aside from serial cell culture or animal passages, the reverse genetic system, which rescues genetically modified attenuated viruses, is now the common approach in generating LAV candidates for both human and animal viral diseases, including PEDV [15,16]. To this end, understanding the molecular biology and identification of virulent/attenuating determinant(s) are necessary for the rational design of potential LAV candidates. Comparison of the genomic differences between the Vero cell-cultured attenuated G2b PEDV and their corresponding parental virulent strains has revealed a common pattern of mutation that particularly affects the S gene [12]. While the observation is reasonable considering the fundamental role of S protein in PEDV infection and induction of host immunity, a recent publication found that a singular S gene exchange had no influence on the virulence of the highly virulent G2b BJ2011C strain and avirulent G1a CHM2013 strain [17]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T29","span":{"begin":0,"end":108},"obj":"Sentence"},{"id":"T30","span":{"begin":109,"end":285},"obj":"Sentence"},{"id":"T31","span":{"begin":286,"end":541},"obj":"Sentence"},{"id":"T32","span":{"begin":542,"end":715},"obj":"Sentence"},{"id":"T33","span":{"begin":716,"end":939},"obj":"Sentence"},{"id":"T34","span":{"begin":940,"end":1245},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"LAVs have been shown to be the most effective way to elicit protective immunity against PEDV infection [12]. Therefore, to combat the emergence of PED as well as to immediately suppress any future outbreaks, studies have been carried out to develop safe and effective vaccines [13,14]. Aside from serial cell culture or animal passages, the reverse genetic system, which rescues genetically modified attenuated viruses, is now the common approach in generating LAV candidates for both human and animal viral diseases, including PEDV [15,16]. To this end, understanding the molecular biology and identification of virulent/attenuating determinant(s) are necessary for the rational design of potential LAV candidates. Comparison of the genomic differences between the Vero cell-cultured attenuated G2b PEDV and their corresponding parental virulent strains has revealed a common pattern of mutation that particularly affects the S gene [12]. While the observation is reasonable considering the fundamental role of S protein in PEDV infection and induction of host immunity, a recent publication found that a singular S gene exchange had no influence on the virulence of the highly virulent G2b BJ2011C strain and avirulent G1a CHM2013 strain [17]."}

{"project":"2_test","denotations":[{"id":"31905842-31689903-144353221","span":{"begin":104,"end":106},"obj":"31689903"},{"id":"31905842-27545066-144353222","span":{"begin":278,"end":280},"obj":"27545066"},{"id":"31905842-27964998-144353223","span":{"begin":281,"end":283},"obj":"27964998"},{"id":"31905842-24967693-144353224","span":{"begin":534,"end":536},"obj":"24967693"},{"id":"31905842-31689903-144353225","span":{"begin":935,"end":937},"obj":"31689903"}],"text":"LAVs have been shown to be the most effective way to elicit protective immunity against PEDV infection [12]. Therefore, to combat the emergence of PED as well as to immediately suppress any future outbreaks, studies have been carried out to develop safe and effective vaccines [13,14]. Aside from serial cell culture or animal passages, the reverse genetic system, which rescues genetically modified attenuated viruses, is now the common approach in generating LAV candidates for both human and animal viral diseases, including PEDV [15,16]. To this end, understanding the molecular biology and identification of virulent/attenuating determinant(s) are necessary for the rational design of potential LAV candidates. Comparison of the genomic differences between the Vero cell-cultured attenuated G2b PEDV and their corresponding parental virulent strains has revealed a common pattern of mutation that particularly affects the S gene [12]. While the observation is reasonable considering the fundamental role of S protein in PEDV infection and induction of host immunity, a recent publication found that a singular S gene exchange had no influence on the virulence of the highly virulent G2b BJ2011C strain and avirulent G1a CHM2013 strain [17]."}