PMC:7019868 / 22229-23360 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7019868","sourcedb":"PMC","sourceid":"7019868","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7019868","text":"In comparison, inoculation with iPEDVPT-P5-96S and iPEDVPT-P96 viruses containing the S gene derived from the attenuated iPEDVPT-P96, induced a delayed onset of clinical symptoms and peak viral shedding. Histological evaluation of piglets inoculated with both viruses (iPEDVPT-P96, n = 3; iPEDVPT-P5-96S, n = 3) at 3 DPI revealed a much milder degree of villous atrophy in the jejunum with conspicuous villous hyperplasia compared to the other two groups. Notably, iPEDVPT-P5-96S-treated piglets exhibited statistically significant severer villous atrophy in jejunum than iPEDVPT-P96-treated piglets (Figure 3). Despite the similar pattern and severity of viral shedding and clinical symptoms, inoculation with iPEDVPT-P5-96S eventually resulted in a higher mortality rate (40% in iPEDVPT-P96 and 80 % and iPEDVPT-P5-96S) and lower average daily weight gain by 10 DPI than those upon inoculation with iPEDVPT-P96. These data suggested that iPEDVPT-P96 fully regained virulence by replacement of the S gene from the virulent PEDVPT 52 strains and the complementary approach can only partially reduce the virulence of the iPEDVPT-P5.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"419","span":{"begin":121,"end":128},"obj":"Chemical"},{"id":"417","span":{"begin":32,"end":42},"obj":"Chemical"},{"id":"418","span":{"begin":51,"end":58},"obj":"Chemical"},{"id":"420","span":{"begin":129,"end":132},"obj":"Chemical"},{"id":"421","span":{"begin":269,"end":276},"obj":"Chemical"},{"id":"422","span":{"begin":289,"end":296},"obj":"Chemical"},{"id":"423","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"424","span":{"begin":476,"end":479},"obj":"Chemical"},{"id":"425","span":{"begin":572,"end":583},"obj":"Chemical"},{"id":"426","span":{"begin":711,"end":718},"obj":"Chemical"},{"id":"427","span":{"begin":781,"end":788},"obj":"Chemical"},{"id":"428","span":{"begin":806,"end":813},"obj":"Chemical"},{"id":"429","span":{"begin":901,"end":908},"obj":"Chemical"},{"id":"430","span":{"begin":940,"end":951},"obj":"Chemical"},{"id":"431","span":{"begin":1120,"end":1130},"obj":"Chemical"},{"id":"432","span":{"begin":354,"end":369},"obj":"Disease"},{"id":"433","span":{"begin":390,"end":421},"obj":"Disease"},{"id":"434","span":{"begin":540,"end":555},"obj":"Disease"},{"id":"435","span":{"begin":846,"end":857},"obj":"Disease"}],"attributes":[{"id":"A432","pred":"tao:has_database_id","subj":"432","obj":"MESH:C564019"},{"id":"A433","pred":"tao:has_database_id","subj":"433","obj":"MESH:D018253"},{"id":"A434","pred":"tao:has_database_id","subj":"434","obj":"MESH:C564019"},{"id":"A435","pred":"tao:has_database_id","subj":"435","obj":"MESH:D015430"},{"subj":"419","pred":"source","obj":"LitCovid-PubTator"},{"subj":"417","pred":"source","obj":"LitCovid-PubTator"},{"subj":"418","pred":"source","obj":"LitCovid-PubTator"},{"subj":"420","pred":"source","obj":"LitCovid-PubTator"},{"subj":"421","pred":"source","obj":"LitCovid-PubTator"},{"subj":"422","pred":"source","obj":"LitCovid-PubTator"},{"subj":"423","pred":"source","obj":"LitCovid-PubTator"},{"subj":"424","pred":"source","obj":"LitCovid-PubTator"},{"subj":"425","pred":"source","obj":"LitCovid-PubTator"},{"subj":"426","pred":"source","obj":"LitCovid-PubTator"},{"subj":"427","pred":"source","obj":"LitCovid-PubTator"},{"subj":"428","pred":"source","obj":"LitCovid-PubTator"},{"subj":"429","pred":"source","obj":"LitCovid-PubTator"},{"subj":"430","pred":"source","obj":"LitCovid-PubTator"},{"subj":"431","pred":"source","obj":"LitCovid-PubTator"},{"subj":"432","pred":"source","obj":"LitCovid-PubTator"},{"subj":"433","pred":"source","obj":"LitCovid-PubTator"},{"subj":"434","pred":"source","obj":"LitCovid-PubTator"},{"subj":"435","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T110","span":{"begin":88,"end":92},"obj":"Body_part"},{"id":"T111","span":{"begin":377,"end":384},"obj":"Body_part"},{"id":"T112","span":{"begin":559,"end":566},"obj":"Body_part"},{"id":"T113","span":{"begin":1001,"end":1005},"obj":"Body_part"}],"attributes":[{"id":"A110","pred":"fma_id","subj":"T110","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A111","pred":"fma_id","subj":"T111","obj":"http://purl.org/sig/ont/fma/fma7207"},{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma7207"},{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma74402"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T21","span":{"begin":377,"end":384},"obj":"Body_part"},{"id":"T22","span":{"begin":559,"end":566},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002115"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0002115"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T25","span":{"begin":410,"end":421},"obj":"Disease"}],"attributes":[{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0005043"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T244","span":{"begin":63,"end":70},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T245","span":{"begin":88,"end":92},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T246","span":{"begin":142,"end":143},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T247","span":{"begin":260,"end":267},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T248","span":{"begin":330,"end":331},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T249","span":{"begin":377,"end":384},"obj":"http://purl.obolibrary.org/obo/UBERON_0002115"},{"id":"T250","span":{"begin":559,"end":566},"obj":"http://purl.obolibrary.org/obo/UBERON_0002115"},{"id":"T251","span":{"begin":749,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T252","span":{"begin":1001,"end":1005},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T253","span":{"begin":1031,"end":1033},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"}],"attributes":[{"subj":"T244","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T46","span":{"begin":188,"end":202},"obj":"http://purl.obolibrary.org/obo/GO_0019076"},{"id":"T47","span":{"begin":656,"end":670},"obj":"http://purl.obolibrary.org/obo/GO_0019076"},{"id":"T48","span":{"begin":967,"end":976},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T49","span":{"begin":967,"end":976},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T50","span":{"begin":1103,"end":1112},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T51","span":{"begin":1103,"end":1112},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"attributes":[{"subj":"T46","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T158","span":{"begin":0,"end":203},"obj":"Sentence"},{"id":"T159","span":{"begin":204,"end":455},"obj":"Sentence"},{"id":"T160","span":{"begin":456,"end":611},"obj":"Sentence"},{"id":"T161","span":{"begin":612,"end":913},"obj":"Sentence"},{"id":"T162","span":{"begin":914,"end":1131},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T158","pred":"source","obj":"LitCovid-sentences"},{"subj":"T159","pred":"source","obj":"LitCovid-sentences"},{"subj":"T160","pred":"source","obj":"LitCovid-sentences"},{"subj":"T161","pred":"source","obj":"LitCovid-sentences"},{"subj":"T162","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T16","span":{"begin":354,"end":369},"obj":"Phenotype"},{"id":"T17","span":{"begin":540,"end":555},"obj":"Phenotype"},{"id":"T18","span":{"begin":846,"end":857},"obj":"Phenotype"}],"attributes":[{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0011473"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0011473"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0004324"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-HP"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#b593ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ec9b"},{"id":"LitCovid-PD-UBERON","color":"#ec93a4"},{"id":"LitCovid-PD-MONDO","color":"#93beec"},{"id":"LitCovid-PD-CLO","color":"#d8ec93"},{"id":"LitCovid-PD-GO-BP","color":"#e593ec"},{"id":"LitCovid-sentences","color":"#93eccb"},{"id":"LitCovid-PD-HP","color":"#ecb193"}]}]}}