2. Methods 2.1. Study Design The study used a qualitative, exploratory, and descriptive design to explore and describe the experiences of nurses caring for TB patients at regional hospital. The researcher wanted to uncover the personal experiences of nurses and the meanings that they attached to the events, processes, and structures of their lives in the TB wards. Therefore, an exploratory and descriptive design was the most suitable design. 2.2. Study Site This study was conducted at a regional hospital in Vhembe district in Limpopo Province, South Africa between 2014 and 2015. The hospital is a public healthcare facility situated in Thohoyandou, Limpopo province of South Africa. It is the only regional hospital in Vhembe district of Limpopo province with two TB wards and 20 beds. It is a referral hospital for seven community hospitals in Vhembe district. According to Wolmarans and Asia [11], the total population is about 1,294,722, comprising of Vha-venda, Va-tsonga, and Sotho speaking people. 2.3. Study Population The study the target population comprised of all nursing staff in all TB wards caring for TB patients at a regional hospital in Vhembe District in Limpopo Province at the time of this study. The total population of nurses working in the TB ward was 22 nurses. 2.4. Sampling Procedure The study used a non-probability purposive sampling method, since it involves selection of individuals for participation based on their knowledge of a phenomenon that is being studied. It was believed that those participants would provide the researcher with the rich data needed to gain insight and discover new meaning in an area of study. The inclusion criteria were all nurses with five years’ experience caring for TB patients since it was believed that they would provide information-rich data. 2.5. Sample Size Determination The estimated sample for the interview was 15 as they met inclusion criteria and 10 participants agreed and consented to participate, and data saturation was reached with six participants. Interviews were terminated when data saturation was reached, that was when information was repeated and when the researcher probed, rephrased questions, and requested clarity but the information kept repeating itself. 2.6. Data Collection Procedure Data was collected through in-depth individual interviews. All participants who signed a written consent form before data collection were included in this study and were interviewed. The researcher explained the purpose of the study to each participant before interviewing them. Participants were assured that confidentiality will be maintained. The interview dates and times were arranged with participants prior to data collection date. Data collection took place between April–July 2015. The interviews were conducted early in the morning as suggested by participants before they could start with their duties to avoid distracting them from their normal ward routine work. Separate interviews with six participants took place in a private office within TB wards at the regional hospital, and each lasted approximately 30 min. All interviews were conducted by the researcher. All interviews started with an opening question: “What is your experience when nursing patients who suffer from TB?” The research participants freely responded to open-ended questions in narrative form using their own words, thus sharing their own perspectives with the researcher. Questions were not planned in an inflexible manner. The questions were not asked in a pre-arranged sequence, but the researcher ensured that all relevant topics were covered and that the research focus was kept in mind. The researcher also asked probing questions to guide participants to elaborate further upon their responses where additional information were required or where unclear answers required more clarity. This resulted in gaining in-depth accounts about participants’ experiences while caring for TB patients. Data was collected by means of audio-recordings, field notes, and in-depth interviews. 2.7. Data Management and Analysis Data was stored in a password-protected computer. Access to the database was restricted to the researcher and supervisors only. Data was stored as per university’s protocols. Any identifiable information that was collected remained confidential and was only accessible to the researcher and supervisors. Data was analyzed in groups not individually to avoid identifying the participants by their responses. Qualitative data analysis always takes place concurrently with data collection. Therefore, the researcher attempted to gather, manage, and interpret a growing bulk of data simultaneously. In this study, the audio-recorded interviews were transcribed and coded immediately after data collection. Data was analyzed using Colaizzi’s [12] methods which comprise the following seven steps:Each research participant’s verbatim transcript was read to acquire a sense of the whole.Significant statements and phrases pertaining to the phenomenon being studied were extracted from each transcript.Meanings were formulated from the significant statements.Meanings were organized into themes, and themes evolved into theme clusters and eventually into theme categories.These results were integrated into a rich and exhaustive description of the lived experience.The essential structure of the phenomenon was uncovered.Validation was sought from the research participants to compare the researcher’s descriptive results with their lived experiences. 2.8. Ethical Consideration The proposal was submitted and presented to the School of Health Science and University Higher Degrees Committee (UHDC) and ethical clearance was granted (SHS/15/PH/07/1604). Permission to conduct the study was obtained from the Limpopo Provincial Department of Health and Vhembe District Department of Health, Nursing Service Manager, and Chief Executive Officer of the regional hospital. Consent forms were given to every participant to complete. The nature of research was described to the participants of the study and they were informed of their right to refuse to participate, or to withdraw from participating if they felt that they could not continue. The participants were also informed and assured that the information they provided would not be used against them or shared with other people but would be reported as findings of the study. Anonymity was also ensured in which the participants did not write down their names or any personal identification. This allowed the participation to be anonymous. The researcher respected the choices and agreements made with the participants. The initial agreement was not changed without the knowledge of the participants. The participants were not victimized for refusing to participate in the study.