One reason more work in animals with spontaneous seizures ultimately became the standard is that methods to induce epilepsy in rodents became available. The fact that the animals had spontaneous seizures was very exciting, and it also shed new light on MTS because a MTS-like pattern of damage occurred using one of the methods that has become most common—inducing status epilepticus (SE) by injection of the glutamate receptor agonist kainic acid37 or cholinergic receptor agonist pilocarpine.38 After the injection, SE occurred within about an hour, and in the ensuing days a MTS-like pattern of neuropathology developed. Within weeks or months, animals exhibited spontaneous limbic seizures in their home cages, and these seizures were convulsive and therefore very compelling. At the time, behavior was the way seizures were judged, so in an animal the most convincing evidence of a seizure was one that is convulsive; the standard now is video-electroencephalogram (EEG).