Another area of major interest was to develop a bona fide animal model of chronic epilepsy. This quest began as the studies of normal animals were increasingly criticized as not necessarily being predictive of what occurs in patients. Although logical, there was a counterargument that many of the current epilepsy medications were based on drug testing in normal animals. Regardless, there is an increasing need for “high throughput” models such as zebrafish,32 organotypic hippocampal cultures,33 patient-derived stem cells,34 and organoids.35 Advances in computational models have also led to new ways to study epilepsy.36