Within the DG, there is more evidence than ever that GCs could be “detonators” and together with CA3 form a focus for seizures. However, the evidence is primarily from animals—not humans. An important consideration is whether the DG is only one area where “detonators” exist, that is, more “ticking time bombs” exist outside of the DG. These additional sites could all be “brain gates,” and targeting these “gates” in epilepsy could be fruitful.