Notably, it was often assumed that MTS led to epilepsy. One argument was the finding that seizures in patients seemed to start in the sclerotic hippocampus.2 Surgical removal often helped, supporting the hypothesis, but did not always stop clinical seizures. How the hippocampus could be important but its removal not provide a cure could be explained by the concept of secondary epileptogenesis,3 where secondary foci assume the role of the primary focus if the primary focus is removed. Still, explaining hippocampal neuropathology continued to attract attention.