Sanchez Fernandez and colleagues compared the diagnostic yield of the 3 most commonly employed genetic tests: CMA, epilepsy gene panels, and exome sequencing. In addition, they evaluated the cost-effectiveness of each platform individually and in combination. To address these questions, they analyzed previously published data from 20 studies and found the overall yield of CMA to be 8%, while epilepsy gene panels came in at 23% and exome sequencing solved an average of 45% of cases. They then used the incremental cost-effectiveness ratio metric to determine that gene panels are the most cost-effective single test (US$15 848 per diagnosis); it is important to note that the gene panels in each study they evaluated varied in the number and combination of genes sequenced, and an optimal panel was not identified. When more than one test is required to make the diagnosis, they found that the most effective strategy is to use an epilepsy gene panel, followed by CMA, followed by exome (US$18 385 per diagnosis); this is a departure from what is often recommended as a standard workup, which is to start with CMA, then gene panel, and finally exome.