When the good response group was defined as ypT0 (Fig. 3A), the values of AUC showed significant differences between the 3 modalities (P < .001). Endoscopy showed significantly higher AUC (0.818) than did mrTRG and combination modality in differentiating good response from poor response (P < .001). Among the 3 modalities, endoscopy showed the highest value and mrTRG showed the lowest value. When the good response group was defined as ypT0-1 (Fig. 3B), the 3 modalities showed no significant differences in differentiating good tumor response from poor response (P = .117). However, the AUC (0.717) of the combination modality was significantly higher than that of mrTRG (P = .011). When the good response group was defined as ypT0-2 (Fig. 3C), the 3 modalities showed significant differences in differentiating good tumor response from poor response (P = .011). The AUC (0.697) of the combination modality was the highest among the methods, and it was significantly higher than that of mrTRG (P = .026).