(a) Time-decay of the Nile Red normalized fluorescence intensity decay in buffer salted solution (pH = 7.4) in the presence of C22G1 alone (red symbols) and C22G1 and heparin (green symbols). The empty red dot at time = 0 is the light fluorescence observed in the presence of Nile Red alone in solution. TEM images of C22G1 showing the spherical self-assembled nanomicelles in the absence (b) and in the presence (c) of heparin. (d) Clotting times measured in pure plasma (gray bars), in plasma + heparin (white bars), and in the presence of plasma + heparin + C22G1 (gray-striped violet bars) by the aPTT and PT assays. Panels (a–c) adapted from [21] and [36], with the permission of The Royal Society of Chemistry.