PMC:6723065 / 5172-6279
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6723065","sourcedb":"PMC","sourceid":"6723065","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6723065","text":"2.1.1. Olfactory Dysfunction\nOlfactory dysfunction is a typical symptom complained about in the early stage of the disease. It seems to affect more than 80% of patients, but only about 40% of them are aware of an impaired sense of smell [21]. A recent study has reported that olfactory dysfunction is associated with decreased dopamine transporter binding in more than 40% of patients [22]. In a small cohort of patients with idiopathic RBD (iRBD), the presence of smell impairment has been detected as a predictive value for conversion to PD and to Parkinson disease with dementia (PDD) over 5 years [23].\nAccording to previous studies, hyposmia seems to be related to neuronal loss in cortico-medial amygdala or to decreased dopaminergic neurons in the olfactory bulb. This disturbance, which generally affects both nostrils, tends to correlate directly with disease duration and severity [24,25]. Furthermore, smell loss has been related to an increased risk of cognitive decline and it is consequently a prodromal symptom of PDD onset. Currently, hyposmia cannot be treated by any anti-PD drugs [26,27].","divisions":[{"label":"title","span":{"begin":0,"end":28}},{"label":"p","span":{"begin":29,"end":606}}],"tracks":[{"project":"2_test","denotations":[{"id":"31434341-9153598-7278217","span":{"begin":238,"end":240},"obj":"9153598"},{"id":"31434341-25298306-7278218","span":{"begin":386,"end":388},"obj":"25298306"},{"id":"31434341-25609758-7278219","span":{"begin":602,"end":604},"obj":"25609758"},{"id":"31434341-12390970-7278220","span":{"begin":892,"end":894},"obj":"12390970"},{"id":"31434341-1538221-7278221","span":{"begin":895,"end":897},"obj":"1538221"},{"id":"31434341-30058142-7278222","span":{"begin":1100,"end":1102},"obj":"30058142"},{"id":"31434341-22584158-7278223","span":{"begin":1103,"end":1105},"obj":"22584158"}],"attributes":[{"subj":"31434341-9153598-7278217","pred":"source","obj":"2_test"},{"subj":"31434341-25298306-7278218","pred":"source","obj":"2_test"},{"subj":"31434341-25609758-7278219","pred":"source","obj":"2_test"},{"subj":"31434341-12390970-7278220","pred":"source","obj":"2_test"},{"subj":"31434341-1538221-7278221","pred":"source","obj":"2_test"},{"subj":"31434341-30058142-7278222","pred":"source","obj":"2_test"},{"subj":"31434341-22584158-7278223","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#eccc93","default":true}]}]}}