Pharmacological studies on VHs in synucleinopathies helped in assessing the role of the different neurotransmitters. Indeed, the importance of dopamine transmission has been significantly reduced in previous years [133,134]. Therapeutic options for PsD of course include antipsychotic agents. However, due to severe motor worsening, typical antipsychotics (e.g., haloperidol, chlorpromazine) should be avoided [135]. On the other hand, atypical antipsychotics seem to be very effective, as a possible consequence of serotonergic modulation on 5-HT2 receptors. Indeed, Clozapine has always been considered to be extremely effective in these patients [136]. However, patients receiving Clozapine must undergo weekly blood count tests. Due to this necessity, Clozapine use is now reserved to second-line treatment of PsD [137]. Quetiapine (total daily dose ranging from 25 mg up to 150–300 mg) use is nowadays very common, and this drug is often considered a first choice, due to its high tolerability [60]. Remarkably, the Food and Drug Administration (FDA) has recently warned about the increased mortality risk in elderly people receiving antipsychotics [138]. Accordingly, antipsychotics should be employed if strictly necessary.