PMC:6723065 / 15940-16710 JSONTXT

{"project":"2_test","denotations":[{"id":"31434341-30361297-7278273","span":{"begin":231,"end":233},"obj":"30361297"},{"id":"31434341-29872418-7278274","span":{"begin":365,"end":367},"obj":"29872418"},{"id":"31434341-22933817-7278275","span":{"begin":368,"end":370},"obj":"22933817"},{"id":"31434341-29872418-7278276","span":{"begin":641,"end":643},"obj":"29872418"}],"text":"2.1.5. Impulse Control Disorder\nImpulse Control Disorder (ICD) (i.e., hypersexuality, gambling, binge-eating, compulsive shopping or hobbying, punding, and homeostatic hedonism disorders) are more frequent in young, male patients [71]. ICD main risk factors include dopaminergic replacement therapy, in particular with DAs (14%–17% of cases), and disease duration [72,73]. In these patients, DA therapy should be discontinued (or at least reduced until ICD cessation) with proportional l-dopa dose adjustment. However, some patients could experience DAWS, with mood, autonomic, and sleep disorders, requiring careful symptomatic management [72].\nOther NMS, which can appear in the early stage but are prominent during the progression of disease, will be later discussed."}