Adverse reaction  Studies  Total patients, n  Patients with adverse reaction, n (%)  (%, min-max) †
Nausea (overall incidence)  [ 2, 18, 27, 33, 45, 46, 48, 53, 55, 57, 59, 60, 67, 84, 90, 93, 109, 118]  2214  257 (12)  (2–41) [ 55] - [ 48]
  Intravenous administration  [ 18, 27, 33, 46, 48, 53, 59, 90, 118]  1154  199 (17)  (2–41) [ 59] - [ 48]
  Transdermal application  [ 2, 45, 55, 57, 67, 93, 109]  1039  51 (5)  (2–32) [ 55] - [ 2]
  >1 administration route  [ 60, 84]  21  7 (33)  (29–36) [ 84] - [ 60]
Vomiting (overall incidence)  [ 2, 18, 27, 33, 46, 48, 55, 57, 59, 118]  1611  115 (7)  (0–64) [ 55] - [ 48]
  Intravenous administration  [ 18, 27, 33, 46, 48, 59, 118]  972  108 (11)  (2–64) [ 59] - [ 48]
  Transdermal application  [ 2, 55, 57]  639  7 (1)  (0–6) [ 55] - [ 2]
Nausea and vomiting ‡  [ 7, 38, 41, 54, 66, 69, 73, 85, 87, 115]  4529  591 (13)  (0–46) [ 66] - [ 73]
Abdominal cramps/stomach  ache (overall incidence)  [ 18, 26, 27, 39, 41, 54, 55, 59, 73, 85, 87, 93, 115]  1629  88 (5)  (1–52) [ 117] - [ 116]
  Intravenous administration  [ 18, 26, 27, 39, 41, 54, 59, 73, 85, 87, 115]  1253  72 (6)  (1–52) [ 18] - [ 26]
  Transdermal application  [ 55, 93]  376  16 (4)  (2–16) [ 55] - [ 93]
Halitosis/garlic-like breath  (overall incidence)  [ 4, 9, 16, 19, 29, 30, 35, 42, 43, 45, 50, 52, 55, 57, 58, 66– 68, 79, 83,  85, 88, 94, 95, 97, 98, 109, 112, 113]  5782  607 (11)  (0–100) [ 30] - [ 19, 43, 45, 83, 98]
  Intravenous administration  [ 16, 85, 94, 98]  239  14 (6)  (1–100) [ 85] - [ 98]
  Transdermal application  [ 4, 19, 29, 30, 42, 45, 50, 52, 55, 57, 58, 66, 67, 79, 83, 88, 95, 109,  112, 113]  5333  556 (10)  (0–100) [ 30] - [ 19, 45, 83]
  Intravesical administration  [ 35, 43, 97]  165  33 (20)  (1–100) [ 35] - [ 43]
  Oral administration  [ 9]  15  4 (27)
Diarrhea (overall incidence)  [ 2, 18, 41, 54, 57, 85, 93]  1107  27 (2)  (1–6) [ 85] - [ 93]
  Intravenous administration  [ 18, 41, 54, 85]  744  15 (2)  (1–6) [ 85] - [ 41]
  Transdermal application  [ 2, 57, 93]  363  12 (3)  (2–6) [ 57] - [ 93]