Flushing was regarded as an allergic reaction in this review and was only reported when DMSO was administered intravenously 25, 40, 41, 51, 54, 73, 74. A total of four studies, not depicted in Table 5, reported 204 cases of flushing during 1439 stem cell infusions 25, 40, 51, 74. Several studies observed a relationship between the dose of DMSO and the occurrence of adverse reactions 67, 75, 78, 83, 88, 93.