Most skin reactions were transient, only lasting minutes 17, 24, 32, 67, 72, but some studies reported cases described as serious, causing discontinuation of treatment 2, 6, 52, 63, 78, 96. There were two studies describing that skin reactions to DMSO would disappear after days of continuous treatment 45, 83. Another study reported that 1 of 18 patients treated for psoriasis with DMSO was hospitalized due to exfoliative erythroderma 63. In another study, two patients, diagnosed with dermographia developed prominent areas of weals after DMSO application 95.