The most common skin reaction was a local burning sensation reported in 13 studies 17, 21, 24, 28, 30, 45, 55, 57, 67, 69, 79, 93, 106. In one study, all participants experienced this burning sensation 45. In the same study, four participants experienced a transient peripheral edema associated with itching and erythema 45. A single study described a burning sensation in four of 669 patients when DMSO was given as a local injection 92; another study described burning in two out of 17 patients when DMSO was injected intraarticularly 103.