Dermatological side effects are common when DMSO is administered transdermally. Skin reactions or allergic reactions were reported in 58 studies. DMSO was applied transdermally in 43 studies 2, 4, 6, 17, 19– 22, 24, 28– 32, 37, 44, 45, 52, 55, 57, 63, 64, 66, 67, 69, 72, 75, 76, 78, 79, 82, 83, 88, 89, 93, 95, 96, 106, 108, 109, 111– 113, intravenously in 14 studies 25, 40, 41, 51, 59, 73, 74, 77, 85, 86, 92, 98, 101, 110 and intraarticular in one 103 ( Table 5).