Cardiovascular and respiratory adverse reactions were reported in 33 studies. Of these, two were randomized controlled trials 33, 59, 30 were cohort studies 7, 18, 23, 25– 27, 36, 39– 41, 51, 54, 61, 65, 66, 68, 73, 74, 80, 85– 87, 90, 100– 102, 104, 115, 117, and one was a preliminary report 91. Except for one study 66, all studies reporting cardiovascular and respiratory reactions administered DMSO intravenously ( Table 3 and Table 4).