One study reported a severe case of nausea, vomiting, and abdominal cramps in one patient with an acute allergic reaction 59. However, in most studies the reported gastrointestinal reactions were transient and mild, often lasting only minutes to a couple of hours 16, 38, 41, 68, 85, 87, 90. Several studies reported a relationship between the dose of DMSO and the occurrence of gastrointestinal adverse reactions 26, 33, 53, 73, 83, 85.