The NADPH oxidase (NOX) family has seven members which are classified into three groups: group 1 is comprised of NOX1, NOX2, NOX3, NOX4; group 2 has NOX5 as the only member, and group 3 is comprised of DOUX1 and DOUX248,332. Increased NOX activity is implicated in many disease states, including hypertension and renal disease5,10,15,23,25,29–32,36,47,48,56,57,125–147,332–344.