Roughly half of the patients develop infection of the exit site [71, 259, 363–376], making visual inspection of the wound at every outpatient visit essential. Additionally, attention should be paid to proper driveline positioning and the use of immobilization devices. A photographic record and clinical scoring of the driveline exit site are helpful in tracking its appearance over time [71, 259, 363–376]. The incidence of infection after LT-MCS implantation depends on patient-related risk factors [71, 259, 363–376].