Patient evaluation and selection for LT-MCS as a therapy for advanced HF involves consideration of multiple factors. LT-MCS is associated with early and late risks of adverse events [3], substantial resource utilization and costs [4, 5], hospital readmissions [6] and the potential for considerable suffering for patients and families [7]. It is therefore crucial that patient selection achieves the greatest treatment effect possible by targeting patients with the highest benefit/risk ratio [8]. Current HF guidelines of the European Society of Cardiology [9] recommend the use of LT-MCS; however, selection criteria for evaluation of potential candidates are lacking. Nonetheless, extensive data are available that predict outcomes with and in the absence of LT-MCS.