1. ABBREVIATIONS AND ACRONYMS  231 2. INTRODUCTION  231 3. METHODS  232 4. PATIENT EVALUATION AND TIMING OF IMPLANTATION  232 5. PREOPERATIVE ORGAN FUNCTION OPTIMIZATION  234 6. CONCOMITANT CARDIAC CONDITIONS INCLUDING ARRHYTHMIAS  235 7. MANAGEMENT OF NON-CARDIAC COMORBIDITIES  236 8. SYSTEM SELECTION  238 9. ANAESTHETIC MANAGEMENT  240 10. OPERATIVE TECHNIQUE  241 11. PAEDIATRIC OPERATIVE TECHNIQUES  243 12. POSTOPERATIVE MANAGEMENT IN THE INTENSIVE CARE UNIT  244 13. ANTICOAGULATION  245 14. REHABILITATION  247 15. OUTPATIENT CARE  247 16. MYOCARDIAL RECOVERY  249 17. PUMP THROMBOSIS AND OTHER LATE ADVERSE EVENTS  250 18. AORTIC INSUFFICIENCY AND LATE RIGHT HEART FAILURE  253 19. INFECTION  254 20. END-OF-LIFE CARE  257 SUPPLEMENTARY MATERIAL  258 ACKNOWLEDGEMENTS  258 REFERENCES  258