19.4 Evidence for assessing a patient for postoperative infection after implantation of mechanical circulatory support The initial evaluation should include a careful history and review of symptoms. Physical examination of surgical wounds, driveline exit site and review of the LT-MCS device function are essential because early detection and treatment of a localized process may prevent progression to more serious VAD infections [26, 363]. In case of driveline exit site infection, the treatment includes increased frequency of dressing change, topical antiseptics and prolonged or lifelong antibiotics (suppressive treatment). In case of ascending driveline infection, surgical revision may be an option.