The seizures in this study are not spontaneous, rather they are induced acutely by systemically injecting either pentylenetetrazol or pilocarpine. Therefore, this study reveals dynamics of a “normal” brain generating seizures rather than of a chronically epileptic brain. The experimenters optogenetically tag PV+ and SST+, allowing them to record from (and stimulate) classified PV+ and SST+ interneurons. The nonchronic nature of the epilepsy they are studying here is especially important to keep in mind when considering SST+ interneurons, as SST+ interneurons in the hippocampus change dramatically during disease progression.2 Miri et al record the activity from both interneuron types during preictal and ictal periods. Both types increase firing preictally and decrease firing after ictal onset. Such increases in interneuron rates prior to seizure have been observed in acute and chronic models of epilepsy,3,4 though for spontaneous seizures it is noteworthy that preictal increases in interneuron rate may reflect normal changes associated with brain state transitions.5