PMC:6610326 / 90546-91220 JSONTXT

{"project":"2_test","denotations":[{"id":"31316328-22958818-38515869","span":{"begin":130,"end":134},"obj":"22958818"},{"id":"31316328-27664945-38515870","span":{"begin":143,"end":147},"obj":"27664945"}],"text":"Neurons utilize most of their energy at the synapse, which consumes more than a third of the overall cellular ATP (Harris et al., 2012; Niven, 2016). The properties and types of ion channels expressed in a MN influence the energy required to generate an action potential, and the Na+/K+ pump is estimated to account for 20–40% of the brain’s energy consumption (Purves et al., 2001). The size and shape of a MN also affects its electrical properties, and the distance over which signals must spread. MNs have particularly high energetic demands, even compared to other neurons. They also have large numbers of NMJs as well as high intracellular Ca2+ flux as discussed above."}

{"project":"0_colil","denotations":[{"id":"31316328-22958818-631326","span":{"begin":130,"end":134},"obj":"22958818"},{"id":"31316328-27664945-631327","span":{"begin":143,"end":147},"obj":"27664945"}],"text":"Neurons utilize most of their energy at the synapse, which consumes more than a third of the overall cellular ATP (Harris et al., 2012; Niven, 2016). The properties and types of ion channels expressed in a MN influence the energy required to generate an action potential, and the Na+/K+ pump is estimated to account for 20–40% of the brain’s energy consumption (Purves et al., 2001). The size and shape of a MN also affects its electrical properties, and the distance over which signals must spread. MNs have particularly high energetic demands, even compared to other neurons. They also have large numbers of NMJs as well as high intracellular Ca2+ flux as discussed above."}