No mutations in specific genes have been reported in dogs with CCD so far. The only neurodegenerative disease in dogs that has been linked to specific mutation is degenerative myelopathy (DM), a condition caused by both demyelination and axonal loss in the canine spinal cord. In dogs with this disease, mutations have been found in a gene SOD1, coding for superoxide dismutase enzyme (Nakamae et al., 2015; Kobatake et al., 2016). Interestingly, this gene is in human patients associated with some forms of familial amyotrophic lateral sclerosis (Rosen et al., 1993). Beside mutations in SOD1 gene, risk for developing DM in dogs, as well as onset of disease, seem to be partially modulated by gene encoding SP110 nuclear body protein (SP110) at least in Pembroke Welsh Corgis (Ivansson et al., 2016). No other mutations or disease modifying loci related to neurodegeneration have been detected in dogs so far and thus, little is known about the potential genetic risks or genetic predisposition for CCD and CAA.