Neurodegenerative diseases do not occur spontaneously in laboratory mice and rats, but do occur in several other mammalian species. Studies of neurodegenerative diseases in animals have shown strong similarities between cognitive dysfunction in dogs and human AD and between AD in humans and most other primates (Cummings et al., 1993; Cummings and Cotman, 1995; Dodart et al., 2002; Chambers et al., 2011; Braidy et al., 2015; Schütt et al., 2016). Canine cognitive dysfunction (CCD), also known as canine cognitive dysfunction syndrome (CDS) or canine dementia affects up to 60% of older dogs, mostly dogs older than 11 years (Fast et al., 2013b). The prevalence of CCD does not differ between breeds (Salvin et al., 2010) and there are no breed specific differences in clinical signs or pathology of the disease. However, as larger dog breeds have shorter life span than the smaller ones (Greer et al., 2007), clinical signs of CCD are more often observed and reported in smaller dogs (Vite and Head, 2014; Schmidt et al., 2015). Due to its similarity with AD, CCD is extremely interesting as a model for human disease. CCD is also a major problem for health of older dogs, and is thus also interesting from the point of view of the development of new veterinary diagnostic procedures/markers and medicines for treating this disease in dogs.