Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease, Huntington’s disease, frontotemporal dementia, amyotrophic lateral sclerosis, and others are a major growing public health problem associated with aging, as aging is the greatest risk factor for neurodegeneration. The global number of people living with dementia more than doubled from 1990 to 2016 (GBD 2016 Dementia Collaborators, 2019). These diseases now affect nearly 50 million individuals, and the incidence is projected to triple by 2050. AD and other dementias are associated with alterations in cell type-specific function, including gliosis, neuronal dysfunction and cell death. The pathognomic cause is the condensation of certain proteins into insoluble aggregates and this aggregates damage vulnerable neurons and glial cells. These inclusions of misfolded proteins build up in the brain during normal aging and during the progression of adult-onset dementias.