Targeted therapy & A2AR antagonism ➣ BRAF inhibitor: PLX4720 (393) ➣ MEK inhibitor: Trametinib (393) ➣ A2AR antagonist: SCH58261 (393) ➣ Melanoma: BRAFV600E-PTEN-deficient mice (393) BRAFV600E LWT1 (393) ➣ Primary tumor expansion rate ↓ (393) ➣ Metastasis formation ↓ (393)