➣ Primary tumor expansion rate ↓ (96, 396, 400, 401) IFN-γ (401) Retained in perforin KO mice (401) ➣ Metastasis formation ↓ (394, 401) Tumor CD73 (394) NK cells > CD8+ T cells (394) ➣ Survival ↑ (394, 396, 401) CD8+ T cells > NK cells (394)