PD-1 ICB & CD38 inhibition ➣ anti-PD-L1mAb: 9G2 (96) ➣ anti-CD38mAb: NIMR-5 (96) ➣ CD38 pharmacologic inhibitor: Rhein (96) ➣ Lung: 344SQ (96) LLC-JSP (96) ➣ Primary tumor expansion rate ↓ (96) ➣ Metastasis formation ↓ (96) ↑ CD8+ T cells (96)↑ CD44hiCD62Llo CD8+ T cells (96)↓ PD-1+TIME3+ CD8+ T cells (96)↑ CD4+ICOS+ T cells (96)↓ Tregs (96)↓ MDSCs (96)