Several interventional treatments are being investigated to address coexisting lesions, especially the treatment option using interventional edge-to-edge repair for functional mitral regurgitation associated with heart failure. The latest evidence on interventional edge-to-edge repair in this patient cohort indicates that in patients whose condition is stable and in high volume centres, this therapy can lead to survival benefits and symptomatic relief from dyspnoea [23]. However, in a more open all-comers trial on functional regurgitation, including severely impaired patients who can also be considered for a heart transplant or MCS, interventional edge-to-edge repair failed to provide a clinical benefit [24].